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I would suggest running at least 3 cards for protection in that case so that they wont reach an unaffordable mana cost from removal(s)

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To determine the total cost of a spell, start with the mana cost or alternative cost you're paying, add any cost increases, then apply any cost reductions (such as that of Blasphemous Act)

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This allows you to use life willy-nilly on things like Aetherflux Reservoir and Necropotence

The player whose turn it is has priority as each step and phase begins, and they receive priority after each spell and ability resolves